NASHVILLE, Tenn. – Vince Young and the Tennessee Titans have run out of magic, at least against the Indianapolis Colts.

Peyton Manning threw for 312 yards and a touchdown, and the Colts held off Tennessee for a 22-20 victory Sunday when the Titans couldn’t pull off a final-drive comeback.

This time, the Titans (1-1) trailed by 13 points instead of 14.

But unlike last December, when Rob Bironas capped a similar comeback with a 60-yard field goal, the Colts collapsed around Young on fourth-and-4. That forced him to lob the ball away in the final seconds.

Manning kneeled down to run out the final seconds as Super Bowl champion Indianapolis (2-0) reminded Tennessee which team remains atop the AFC South.

Adam Vinatieri had one of his worst days in years despite making field goals of 22, 39 and 20 yards.

He had an extra point blocked and a field goal partially blocked that bounced off the crossbar before going over. He also missed a 36-yarder to the left after the Colts recovered a fumble in the fourth quarter.

AP-ES-09-16-07 1615EDT