WASHINGTON (AP) – Relief may be on the way for all those youngsters trembling at the thought of another needle jab. One day the flu vaccine may simply be placed under the tongue.

Korean researchers say the new vaccine worked in mice, avoiding not only the painful prick but also the discomfort some people feel from the inhaled vaccine.

The team led by Dr. Mi-Na Kweon of the International Vaccine Institute in Seoul reported their findings in Monday’s online edition of Proceedings of the National Academy of Sciences.

Better ways of delivering vaccine have long been under study, ranging from orally to inhaled, but all seem to have drawbacks.

Now, Kweon and colleagues say, two doses of influenza vaccine under the tongue of mice primed the animals’ immune system to fight off what would otherwise have been a deadly dose of flu.

Next, they are turning their attention to people, to see if under-the-tongue vaccine also prompts a strong immune response.

Placing a couple of drops of liquid under the tongue gets the vaccine directly to mucus membranes and prompts a response both in mucus tissues throughout the body as well as in the immune system itself, the researchers said.

“These studies provide a basis for further human testing of this alternative form of needle-free vaccination. Aside from its convenience, sublingual vaccination appears to disseminate immunity to a broader range of organs than the classical routes of injecting or ingesting vaccines,” said Dr. Cecil Czerkinsky, deputy director-general for laboratory science at the Institute.

“If these findings are replicated in humans, they could pave the way for the development of a new generation of vaccines that could be used for mass vaccination against respiratory infections, including the pandemic avian-human influenza viruses,” he said in a statement.

Several research efforts applying vaccine to mucus membranes have been tried, seeking to avoid both the needle sticks that people dislike and the harsh environment of the digestive system that can damage or destroy a vaccine. Studies of under-the-tongue of other medicines have also been done.

Dr. William Schaffner of Vanderbilt University noted that recent flu studies have involved nasal sprays.

However, he said while he had expected people to be averse to needles, he was surprised to discover that “many people are averse to people messing with their nose … so there are limitations to nasal spray.”

So for researchers looking for another means of doing this, “just a drop under the tongue at least will protect mice … that’s a very exciting and promising line of investigation,” said Schaffner, who was not part of the research team.

And, he added, “if we were faced with a pandemic, the easier and more acceptable we can make the distribution of the vaccine the more rapidly we can protect a proportion of population.”

Kweon also said that with a nasal spray there might be a chance of a vaccine affecting the central nervous system, which is not a risk of the under-the-tongue vaccine.

The under-the-tongue vaccine worked whether it was a live or inactivated virus, Kweon reported. And, she added, it could also be flavored to make it more acceptable.

On the Net:

Proceedings of the National Academy of Sciences: http://www.pnas.org

International Vaccine Institute: http://www.ivi.int

AP-ES-01-28-08 1435EST

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