MONTCOAL, W.Va. (AP) — Rescuers drilled into the coal mine where 25 people died in an explosion, hoping to vent enough poisonous gas to safely get inside Wednesday and look for possible survivors.

Crews had drilled one hole and were working on two more to release enough methane gas so searchers could enter the Upper Big Branch mine to look for four people still missing in the worst U.S. mining accident in more than two decades.

“The rescue teams are prepared,” West Virginia Gov. Joe Manchin said at a briefing Wednesday morning. “They’re charged up, ready to go.”

Investigators believe a buildup of methane contributed to the explosion, and the mine has repeatedly been cited for problems with its ventilation system, which clears away the highly combustible gas. Like many other mine operators, owner Massey Energy Co. frequently sidesteps hefty fines by aggressively appealing safety violations at the mine, according to an Associated Press analysis of mine safety records.

Rescuers hoped the four miners might somehow have reached a chamber where they could survive for four days, though they acknowledged the odds were against them. They banged on a drill pipe for about 15 minutes after the first hole was complete but got no response.

They later planned to set off small explosions on the surface to send a seismic signal to the mine. Miners are trained to bang back on the drill’s casing, and sections of mine roof contain numerous metal bolts that trapped miners can bang on to signal their presence.

It’s not clear how long it will take to vent enough methane so rescuers can enter the mine. Once they do, it will take four or five hours to get far enough inside to check for survivors, who would be about 1,000 feet below the surface.

Seven bodies were pulled out after the explosion, and two miners were hospitalized. Manchin said Wednesday that one was doing well and the other was in intensive care. Emergency workers were able to identify four of the 18 bodies still in the mine before poisonous gas forced them out Monday.

The quality and quantity of coal produced at Upper Big Branch make the mine one of gems of Massey’s operation. The mine produced more than 1.2 million tons of coal last year and uses the lowest-cost underground mining method, making it more profitable. The mine produces metallurgical coal that is used to make steel and sells for up to $200 a ton — more than double the price for the type of coal used by power plants.

Federal regulators probing the explosion plan to review Massey’s safety violations, many of which involved venting methane gas. If the odorless, colorless gas is not kept at safe levels, a small spark can ignite it.

The Mine Safety and Health Administration on Wednesday appointed a special team of investigators to look into the blast. It includes safety officials from outside the district normally responsible for enforcement at the mine.

Massey is still contesting more than a third of all its violations at the Montcoal, W.Va., mine since 2007. In the past year, federal inspectors have proposed more than $1 million in fines for violations at the mine. Only 16 percent have been paid.

Bombarding federal regulators with appeals is an increasingly common industry tactic since the 2006 Sago mine disaster that killed 12 led to stiffer fines and new enforcement to punish the worst offenders, according to AP’s review of records from the Mine Safety and Health Administration.

In an interview Tuesday with AP, Massey CEO Don Blankenship downplayed the link between the ventilation system and the accident.

“I don’t know that MSHA thought there was a problem,” he said.

He said the families of those killed were angry and made “a lot of derogatory comments” during meetings with company officials. He said he did not directly address them.

“They’re looking for some way to release their anger and that’s just the way it is,” he said.

He said the chances of miners making it out of the violent explosion alive were dim, and “I think it dims every day.”

The death toll in Monday’s explosion was the highest in a U.S. mine since 1984, when 27 people died in a fire at Emery Mining Corp.’s mine in Orangeville, Utah. If the four missing bring the total to 29, it would be the most to die in a U.S. coal mine since a 1970 explosion killed 38 at Finley Coal Co. in Hyden, Ky.

In the area about 30 miles south of Charleston where coal is king, people anxiously awaited word on the missing.

Larry Asbury’s son is on a mine rescue team. He joined about 50 mourners who packed the creaky pews of the modest St. Joseph Catholic Church a few miles from the disaster to honor the victims and pray that the missing turn up safe.

“The coal community is coming together and praying for miners and their families,” he said. “It’s just so important to show the community this kind of support.”

Manchin said the first drill hole entered the section of the mine about a football field’s length away from a rescue chamber where officials hope the miners sought refuge.

Searchers would have to navigate in the darkness around debris from structures shattered by the explosion and around sections of track that were “wrapped like a pretzel,” said Kevin Stricklin, an administrator from the federal Mine Safety and Health Administration.

“There’s so much dirt and dust and everything is so dark that it’s very easy, as hard as it may seem to any of us outside in this room, to walk by a body,” Stricklin said.

Though the situation looked bleak, the governor pointed to the 2006 Sago Mine explosion that killed 12. Crews found miner Randal McCloy Jr. alive after he was trapped for more than 40 hours in an atmosphere poisoned with carbon monoxide.

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Associated Press writers Greg Bluestein, Allen G. Breed, Vicki Smith, Tom Breen, Tim Huber and John Raby in West Virginia and Sam Hananel in Washington contributed to this report.