Lewiston (0-1) at Oxford Hills/Buckfield (0-1)

Friday, 7 p.m.

Vikings trying to extend their winning streak in this series and coming off solid first half at Cheverus. Devils look to recover from one-sided loss to No. 1 Windham.

Brewer (1-0) at Mt. Blue (1-0)

Friday, 7 p.m.

Game of the Year candidate won on a Cougars’ Hail Mary last October. Both teams among favorites in Class B North because defenses appear dramatically improved.

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Morse (1-0) at Leavitt (1-0)

Friday, 7 p.m.

Both teams hit hard by injuries in opener. Hornets still have healthy combination of QB Levi Green and WR Max Green, who carried them to win at Westbrook.

Mtn. Valley (0-1) at Yarmouth (1-0)

Friday, 7 p.m.

Tough matchup for Falcons after first-ever loss to Gray-New Gloucester. Defense will have to be substantially better against big plays, or this one will be over early.

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Spruce Mtn. (0-1) at Lake Region (0-1)

Friday, 7 p.m.

Turnovers and penalties flustered Phoenix in tough opening loss at Wells. Lakers haven’t had much luck in this series but were solid in Week 1 loss to Yarmouth.

Poland (1-0) at Cape Elizabeth (1-0)

Friday, 7 p.m.

Knights fought back from four-touchdown deficit only to lose on late field goal a year ago. They’re still looking for that signature win against an upper-level Class C South opponent.

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Traip (1-0) at Winthrop/Monmouth (0-1)

Friday, 7 p.m.

Could be a defensive struggle, especially if Ramblers don’t take better care of the football this week. Rangers’ exhibition loss to Lisbon and win over Boothbay both were 6-0 scores.

Dirigo (1-0) at Oak Hill (1-0)

Saturday, 1:30 p.m.

Recent trend is that the teams meet twice a year, and regular-season loser gets revenge in the playoffs. That won’t stop two high-powered offenses (98 total points in Week 1) from trying to take this one.

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Old Orchard Beach (0-1) at Lisbon (1-0)

Saturday, 1:30 p.m.

Both teams hit hard by graduation since Class D South semifinal a year ago, but the Greyhounds exhibited their blend of grit and firepower in huge win at Winthrop/Monmouth.

Gray-NG (1-0) at Fryeburg (0-1)

Saturday, 1:30 p.m.

Natural rivals in most sports haven’t met in a while on the gridiron. Raiders’ drop from Class B, Patriots’ dismissal of long losing streak are the sidebars here.

Edward Little (1-0) at Portland (1-0)

Saturday, 7 p.m.

Clash of wills and styles here, with Eddies and QB Matt Verrill airing it out against Bulldogs and potent backfield of Joe Esposito and George Lapine.

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