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Ramon Urias, center, is greeted by Austin Hays, left, and Pedro Severino after scoring the winning run Thursday in Baltimore’s 10-inning, 4-3 victory against the New York Yankees. Gail Burton/Associated Press

BALTIMORE — Cedric Mullins delivered a winning sacrifice fly in the 10th inning, Trey Mancini had his first three-hit game since returning from colon cancer surgery, and the Baltimore Orioles beat the New York Yankees 4-3 Thursday for a four-game series split.

Mancini had an RBI single in the first and hit a tying solo homer in the sixth on a flat cutter from Jordan Montgomery, who shook off the initial sign from catcher Gary Sánchez. The 29-year-old Mancini had his first back-to-back multi-hit games since Sept. 23-24, 2019. Mancini missed the 2020 season while being treated for cancer.

Austin Hays put the Orioles ahead 3-2 in the eighth with an RBI double off Darren O’Day, as Cedric Mullins scored from first while center fielder Aaron Hicks had trouble getting the ball out of his glove.

Pinch-hitter Mike Ford, batting for Clint Frazier, walked against César Valdez leading off the ninth and Gleyber Torres fouled off a pair of pitches, then drove the third straight changeup to left-center for a tying ground-rule double. DJ LeMahieu was stranded at third when Gio Urshela lined out.

Pat Valaika sacrificed off Jonathan Loaisiga (2-1) leading off the 10th, moving automatic runner Ramón Urías to third. Mullins flied to center, and Valaika easily scored.

Tanner Scott (1-2) pitched a scoreless 10th for the Orioles, who are 4-10 at home.

New York went 3 for 14 with runners in scoring position and finished a 5-3 trip that started in Cleveland. The Yankees dropped into a last-place tie with Baltimore in the AL East at 11-14.

ATHLETICS 3, RAYS 2: Matt Chapman homered and hit a go-ahead double with two outs in the ninth inning, leading Oakland to a win in St. Petersburg, Florida.

Shane McClanahan, a Tampa Bay left-hander who turned 24 on Wednesday, made an unusual regular-season debut, becoming the fourth player to appear in the regular season after first playing in the postseason.

Throwing at up to 100.5 mph, he was given a 1-0 lead when Austin Meadows hit an RBI double in the first off Chris Bassitt.

Ramón Laureano’s run-scoring double tied the score in the third, and Chapman put Oakland ahead 2-1 in the fourth with his fourth homer this season. Brandon Lowe tied the score an inning later with his fourth homer.

Jed Lowrie drew a walk off Diego Castillo (0-2) with one out in the ninth, Sean Murphy flied out, and Chapman doubled over the glove of right fielder Brett Phillips, who tried for a leaping catch at the front of the warning track.

MARINERS 1, ASTROS 0: Yusei Kikuchi took a no-hit bid into the seventh inning, Taylor Trammell homered and Seattle won at Houston to avoid a four-game series sweep.

Kikuchi (1-1) did not allow a hit until Carlos Correa doubled to deep right-center with one out in the seventh. That was the only hit allowed by Kikuchi, who pitched seven innings, struck out seven and walked two, throwing 61 of 95 pitches for strikes.

Trammell hit his fourth home run of the season in the third inning, a drive off Houston starter Luis Garcia (0-3) that appeared to graze the glove of a leaping Chas McCormick at the right-field wall.

WHITE SOX 3, TIGERS 1: Carlos Rodon (4-0) struck out a career-high 12 in six innings in a doubleheader opener, sending visiting Detroit to its 11th loss in 13 games.

Rodon (4-0) allowed two hits and walked one, and his ERA rose from 0.48 to 0.72. Jonathan Schoop’s RBI double was just the second earned run he has allowed.

Casey Mize (1-3) lost his third straight start. Billy Hamilton hit a tying groundout in the fifth, and Leury Garcia followed with a two-run single.

NATIONAL LEAGUE

CARDINALS 4, PHILLIES 3: Tyler O’Neil scored on David Hale’s wild pitch in the 10th inning, and St. Louis split its four-game series against visiting Philadelphia.

O’Neil, the automatic runner, started on second and advanced on Andrew Knizer’s groundout. Hale (0-1) bounced a curveball past catcher J.T. Realmuto, getting the loss in his first decision since the Phillies acquired him from the New York Yankees last August.

Alex Reyes (1-0) pitched two perfect innings.

BREWERS 2, DODGERS 1: Travis Shaw hit a two-run homer in the fourth inning off Trevor Bauer, Eric Lauer won in his first start of the season and Milwaukee beat visiting Los Angeles.

It was the first meeting of the two teams since the first round of last year’s NL playoffs, a two-game sweep by the World Series champion Dodgers.

Bauer (3-1) allowed four hits, but the one that hurt was Shaw’s in the fourth. After Avisaíl García walked, Shaw drove a 2-2 curveball over the wall in right. Bauer went eight innings and struck out six.

Shaw leads the Brewers with 19 RBI.

CUBS 9, BRAVES 3: Jason Heyward drove in two runs with two hits and Chicago emerged from its hitting slump, ending a five-game losing streak with a win at Atlanta.

The Cubs had 16 hits, topping their combined total of 13 in the first three games of the series. Jake Marisnick hit a homer in the seventh and every Chicago starter had at least one hit.

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