CHICAGO — Jake Burger hit a three-run homer off Rich Hill, Lucas Giolito overcame a shaky first inning and the Chicago White Sox beat the Red Sox 3-1 Wednesday night to end Boston’s six-game winning streak.

The White Sox won for the fourth time in six games and moved over .500 to 22-21.

Burger, recalled Tuesday from Triple-A Charlotte after Luis Robert was placed on the COVID-19 injured list, hit an 0-2 breaking pitch in the fifth inning that traveled an estimated 444 feet.

Giolito (3-1) threw 27 pitches in the first but still allowed fewer than two runs for the fourth time this season.

Hill (1-2) held the White Sox hitless through four innings but lost his lead quickly. Jose Abreu led off the fifth with an opposite-field double to right, and AJ Pollock reached on a throwing error by third baseman Rafael Devers that preceded Burger’s homer.

Liam Hendriks got the final four outs to earn his 14th save in 17 tries.

Hill extended his streak of allowing four earned runs or fewer to 79 starts, the longest active stretch in the majors.

He had no margin for error, as the Red Sox were 1 for 9 with runners in scoring position. Boston averaged nine runs per game during their winning streak but stranded 10 runners Wednesday.

Alex Verdugo’s two-out single scored J.D. Martinez in the first, but the Red Sox failed to add more despite putting runners in scoring position in each of the first four innings against Giolito.

Giolito retired his final seven batters, capped by a diving catch by right fielder Andrew Vaughn that robbed Christian Vazquez of a hit to end the sixth.

The Red Sox loaded the bases with two outs in the seventh against Aaron Bummer and Kendall Graveman, but Verdugo grounded to second.

White Sox reliever Joe Kelly struck out two in the eighth but walked slowly off the field due to left hamstring tightness. He will be evaluated Thursday morning.

The start of the game was delayed by 30 minutes because of rain.