SEATTLE – Drew Bledsoe went all the way home to Washington state to help the Buffalo Bills collect a rare road win.

Willis McGahee had 116 yards rushing and four touchdowns, leading Buffalo to a 38-9 win over Seattle on Sunday, the worst loss for coach Mike Holmgren in his six seasons with the Seahawks.

Bledsoe offset his three interceptions by completing two-thirds of his passes for 275 yards and a touchdown, and the Bills (5-6) snapped a six-game road losing streak dating to last season.

It was Buffalo’s first road win in five tries this season and the team’s second victory in the last 12 trips.

McGahee led the way behind an offensive line that dictated the pace all day. He scored on a pair of 2-yard runs, took a lateral from Bledsoe for a 30-yard TD and added a 1-yard scoring run midway through the fourth quarter.

The Seahawks (6-5) hit their lowest point this season with an abysmal performance that nearly emptied the stadium of 66,271 fans at the 5-minute mark.

They lost for the second time in five home games after going 8-0 on their own field last season. It also eclipsed the most lopsided loss of Holmgren’s tenure, a 31-3 defeat at Oakland on Oct. 22, 2000.

Bledsoe, who grew up in Walla Walla, Wash., and played college football at Washington State, spread his passes among nine receivers. He finished 25-of-37 for 275 yards, including a 3-yard TD pass to rookie Lee Evans.

Even Bledsoe’s interceptions didn’t hurt the Bills because the Seahawks couldn’t capitalize on them.

Seattle’s Matt Hasselbeck returned from a bruised thigh that sidelined him last week. While he didn’t seem slowed by the injury, he never could established any tempo for Seattle’s offense.

Hasselbeck was 19-of-38 for 185 yards with one TD and one interception. He had a ball knocked away by Buffalo’s Ryan Denney in the fourth quarter, a fumble that led to McGahee’s final touchdown.

Shaun Alexander, the NFL’s leading rusher, was held to 39 yards on 13 carries.

The Bills took control from the start, moving 60 yards in 10 plays on the opening drive. Seattle’s Josh Brown gave them a short field by kicking the ball out of bounds, and McGahee put Buffalo up 7-0 on a 2-yard plunge.

The Bills led 17-3 at halftime, padding the advantage when Bledsoe tossed a 3-yard TD pass to Evans in the right corner of the end zone. Buffalo took over with 2:59 and worked the clock to score with 6 seconds to the break.

Buffalo didn’t punt until less than a minute remained in the third period, and the Seahawks struggled without injured linebackers Chad Brown and Anthony Simmons.

Former Seahawks kicker Rian Lindell missed a 53-yard field goal attempt for Buffalo midway through the third quarter, but the Bills got another chance because Maurice Morris was penalized for illegally leaping off a teammate’s back. The drive continued, and Buffalo led 24-3 after McGahee’s second TD.

There were plenty of other Seahawks mistakes. To list a few: Darrell Jackson had at least three dropped passes and rookie Niko Koutouvides flattened Nate Clements after Buffalo’s punt returner signaled for a fair catch.

The Bills converted 7 of 8 third-downs in the first half. They almost kept the momentum going when Lindell successfully recovered his onside kick to start second half, but Bledsoe threw his third interception.

AP-ES-11-28-04 1932EST