FORT MYERS, Fla. (AP) – Boston’s Curt Schilling outpitched Minnesota ace Johan Santana in a spring training matchup of two of the best pitchers in the major leagues.

Schilling allowed two hits in 4 2-3 shutout innings to help the Red Sox beat the Twins 5-4 Wednesday night. He struck out one and didn’t walk a batter, finishing a test run of his new changeup.

“It depends on the day,” Schilling said of how the changeup has been going. “How it feels. The hitters. The game plan. All of it.” The Red Sox trotted out their opening-day lineup, and Santana said he noticed. The reigning AL Cy Young Award winner gave up four runs and eight hits in five innings.

“You know what?” Santana said. “I feel good. I was working on my changeup. I threw a lot of changeups, and that’s what they were looking for.

“They have one of the best lineups in the game, for sure. It puts you in a situation where you have to show where you are. When you go against a team like that, that’s the way it’s going to be. That’s the way it’s going to be after April 2.”

Twins manager Ron Gardenhire said Santana’s outing did not trouble him.

“All I know is, he’s ready to start on opening day,” Gardenhire said. Following Santana will be Boof Bonser, Ramon Ortiz, Sidney Ponson and Carlos Silva, although the order has yet to be announced by Gardenhire.

The Twins gave Silva a spot in their rotation Wednesday and sent Matt Garza to Triple-A Rochester. Manny Ramirez hit a two-run double in the second for the Red Sox. Julio Lugo and Kevin Youkilis each hit run-scoring singles in the third as Boston built a 4-0 lead.

Notes: The Red Sox placed right-handers Matt Clement and Mike Timlin and left-hander Jon Lester on the 15-day disabled list, retroactive to March 23. Timlin is recovering from an oblique strain and hopes to pitch in a minor league game this weekend. Lester is expected to start the season on a rehabilitation assignment at Single-A Greenville.

AP-ES-03-28-07 2304EDT