DETROIT – Curtis Granderson led off the first inning with an inside-the-park homer and the Detroit Tigers beat the New York Yankees 5-4 on Sunday.

The Tigers have won two of three from New York and can win their first series since mid-July with a victory Monday night.

Bobby Seay (1-0) was awarded the win after pitching two scoreless innings of relief. The Tigers needed five pitchers after rookie starter Jair Jurrjens left in the second inning because of a sore shoulder.

Phil Hughes (2-2) lost for the first time since his major league debut on April 26. He allowed five runs and four hits, including three homers, in six innings. He walked one and struck out six.

The Tigers had only four hits, none after the third inning.

Angels 3, Blue Jays 1

ANAHEIM, Calif. – Kelvim Escobar recorded his career-high 15th victory, Garret Anderson homered and the Angels beat the Blue Jays to earn a split of the four-game series.

Anderson opened the scoring in the fourth with his ninth homer and 250th of his career, becoming the 17th player in history with at least 250 home runs, 2,000 hits, 1,000 RBIs and 450 doubles with one franchise.

Indians 5, Royals 3

KANSAS CITY, Mo. – Travis Hafner and Victor Martinez singled home runs with two out in the 11th inning as the Indians rallied past the Royals.

Hafner’s single off John Bale, the sixth Royals pitcher, scored Franklin Gutierrez, who led off the inning with a walk and moved to second on a sacrifice bunt.

Twins 11, Orioles 3

BALTIMORE – The Twins ended Erik Bedard’s nine-game winning streak and completed a season’s sweep of the Orioles, getting two triples and two RBIs from Jason Bartlett.

Devil Rays 7, Athletics 4

ST. PETERSBURG, Fla. – Carlos Pena hit two homers, and Joel Guzman had a two-run triple during a three-run fifth inning as the Devil Rays beat All-Star Dan Haren and the Athletics.

Phillies 14, Padres 2

PHILADELPHIA – Ryan Howard homered and drove in four runs as the Philadelphia Phillies snapped a four-game losing streak.

Howard, the reigning National League MVP, ended a season-high 11-game homerless drought.

Cardinals 4, Braves 1

ST. LOUIS – Adam Wainwright allowed a run in seven sharp innings, Juan Encarnacion homered and St. Louis handed Atlanta its fifth loss in six games.

Rockies 10, Nationals 5

DENVER – Matt Holliday homered, doubled and drove in three runs, and Colorado finished off a sweep of Washington to move back within 3 games in the wild-card race.

Giants 5, Brewers 4

SAN FRANCISCO – Pedro Feliz scored from first base on Rich Aurilia’s single to right field in the eighth inning, and San Francisco finished off a three-game sweep of slumping Milwaukee.

Reds 9, Marlins 3

CINCINNATI – Catcher Ryan Jorgensen’s first grand slam helped 29-year-old Tom Shearn win his long-awaited major league debut, and Cincinnati won its sixth straight.

The rookie pitcher and his minor-league catcher kept the Reds on their best surge of the season. Since interim manager Pete Mackanin took over on July 3, Cincinnati has the NL’s best record at 29-19.

The foundering Marlins have lost 11 of 12, falling a season-high 17 games under .500 at 57-74.

Shearn (1-0), called up from Triple-A Louisville before the game, limited the Marlins to four hits in seven innings, including Dan Uggla’s three-run homer.

Jorgensen, his catcher at Louisville before an Aug. 14 promotion, hit his first career grand slam in the first inning off rookie right-hander Daniel Barone (0-2) to help Shearn settle in. Brandon Phillips and Edwin Encarnacion also homered off Barone.

Astros 5, Pirates 4

HOUSTON – Ty Wigginton hit a go-ahead two-run homer in the eighth inning, and Houston rallied to avoid a sweep.

Houston trailed 4-1 before scoring twice in the sixth. Luke Scott then hit a one-out double in the eighth and Wigginton hit the first pitch he saw from reliever Shawn Chacon (4-4) to left field, his 19th homer of the year.

It was Wigginton’s third home run since coming to the Astros in a July 28 trade with the Tampa Bay Devil Rays.

Mark McLemore (3-0) went two innings in relief of Wandy Rodriguez, allowing one hit with three strikeouts. Brad Lidge pitched the ninth for his 13th save in 19 tries.