ORCHARD PARK, N.Y. – Making his first career start in place of injured J.P. Losman, Trent Edwards went 22-of-28 for 234 yards, including a 1-yard touchdown to Michael Gaines with 7 minutes left.

With the third-round draft pick, the Bills produced their most points, total yards (304), yards passing and first downs (19) of the season, and helped erase the frustrations of an 0-3 start that included two 20-point losses.

Jabari Greer’s interception of Chad Pennington’s pass at the Jets 25 set up Gaines’ score that put Buffalo ahead 17-7. Terrence McGee’s interception at the Bills 31 ended the Jets’ last-gasp drive with 6 seconds remaining.

Giants 16, Eagles 3

EAST RUTHERFORD, N.J. -With Hall of Famer Lawrence Taylor on hand as an honorary captain, Osi Umenyiora had a team-record six sacks and the Giants (2-2) set a franchise record and tied a league mark by sacking Donovan McNabb 12 times.

Mathias Kiwanuka added three sacks, Justin Tuck two and Michael Strahan one in an awesome display by a defense that was ranked as the worst in the league after giving up 80 points in its first two games.

Kawika Mitchell returned a fumble 17 yards for a touchdown.

Lions 37, Bears 27

DETROIT – Jon Kitna threw two touchdown passes in the fourth quarter and Detroit overcame mistakes and missed opportunities to beat Chicago.

It was the kind of game Detroit used to lose as the league’s laughingstock, but these might not be the same-old Lions, who are 3-1.

Raiders 35, Dolphins 17

MIAMI – Daunte Culpepper ran for three touchdowns and threw for two to win the grudge game against his former team. His much-scrutinized knee might not be 100 percent, but it was good enough to lead the Raiders (2-2).

Culpepper threw only 12 times and completed five for 75 yards, but hit Jerry Porter for scores of 7 and 27 yards.

Cowboys 35, Rams 7

IRVING, Texas – Tony Romo had a 15-yard touchdown run and threw touchdown passes of 59, 37 and 17 yards, turning what had been a tight early game into yet another easy win for Dallas and another frustrating loss for St. Louis.

Romo was 21-of-33 for 339 yards and three touchdowns, with an interception. He also had a long scramble on a fumble that helped keep alive the Cowboys’ first scoring drive.

Chiefs 30, Chargers 16

SAN DIEGO – With Philip Rivers melting down, the Kansas City Chiefs shocked the Chargers, scoring 24 straight points in the second half and getting huge plays from two rookies.

Dwayne Bowe, the Chiefs’ first-round draft pick, caught a go-ahead, 51-yard touchdown pass from Damon Huard early in the fourth quarter. Cornerback Tyron Brackenridge, a rookie free agent, raced 50 yards for a score after Rivers was sacked and fumbled.

Browns 27, Ravens 13

CLEVELAND – Derek Anderson threw two touchdown passes and Jamal Lewis ran for one against his former team.

Lewis, released by Baltimore coach Brian Billick in March, got some satisfaction against his former coach and the team he played with for seven seasons.

Falcons 26, Texans 16

ATLANTA – Joey Harrington threw a pair of touchdown passes to Michael Jenkins, 47-year-old Morten Andersen kicked four field goals and the Falcons defeated Matt Schaub and the Texans.

Jenkins hauled in scoring passes of 5 and 7 yards, the first two-touchdown game of his up-and-down career.

Colts 38, Broncos 20

INDIANAPOLIS – Indianapolis relied on flawless execution to score on six of its last eight possessions, adding yet another anguishing chapter to Denver’s recent rivalry with Indy.

Peyton Manning finished 20-of-27 for 193 yards and three touchdowns, while Joseph Addai ran 19 times for 136 yards and one score.

Cardinals 21, Steelers 14

GLENDALE, Ariz. – Rookie Steve Breaston returned a punt 73 yards for a touchdown and the Cardinals’ defense shut down Pittsburgh’s high-scoring offense most of the day to hand the Steelers their first loss.

Seahawks 23, 49ers 3

SAN FRANCISCO – Matt Hasselbeck passed for 281 yards and two touchdowns, Rocky Bernard ended Alex Smith’s day early with a punishing sack and the Seahawks claimed early supremacy in the NFC West.

Deion Branch had seven catches for 130 yards.

Bucs 20, Panthers 7

CHARLOTTE, N.C. – Jeff Garcia didn’t throw an interception for the fourth straight game and ran for a touchdown, while Tampa Bay shut down David Carr, Steve Smith and Carolina.

to move atop the NFC South.

The 37-year-old Garcia completed 15 of 25 passes for 176 yards.

and got Tampa Bay on the board with a 3-yard scramble on the Bucs’ first possession.

Ike Hilliard caught seven passes for 114 yards, Michael Pittman rushed for 90 yards and the Buccaneers (3-1) overcame the loss of running back Carnell “Cadillac” Williams to a right knee injury to beat the Panthers (2-2) for only the second time in nine meetings.

Starting in place of Jake Delhomme, who was nursing a strained right elbow, Carr completed just 19 of 41 passes for 155 yards. The Panthers avoided their first shutout in five years when Carr’s screen pass to DeAngelo Williams turned into a 24-yard touchdown with 23 seconds left.