CLEVELAND – Edgar Renteria hit a grand slam, Miguel Cabrera also homered and drove in five runs, and the resurgent Detroit Tigers roughed up struggling Cy Young Award winner C.C. Sabathia in a 13-2 victory over the Cleveland Indians on Wednesday night.

Cabrera finished with four hits, and Renteria’s fifth-inning slam capped Detroit’s offensive outburst against Sabathia (0-3), who has a 13.50 ERA after four outings. That’s one big reason for Cleveland’s slow start – the Indians (5-10) have lost three straight and eight of 11.

With newcomers Renteria and Cabrera finding their strokes, Detroit’s loaded lineup has broken loose after an early slump. The Tigers have scored 30 runs while winning their past three games following a 2-10 start.

After failing in two starts during the 2007 AL championship series against Boston, then opening this year with three poor performances, Sabathia was looking to get untracked against the Tigers, Cleveland’s AL Central rival.

Instead, he was soundly booed as he walked slowly to the dugout after giving up nine runs, eight hits and five walks over four-plus innings. The Indians lost for the sixth time in seven games.

Sabathia, who can become a free agent after this season, has walked 14 and yielded 32 hits in 18 innings. A year ago, he walked only 37 in 241 innings while going 19-7 with a 3.21 ERA to win the AL Cy Young Award.

In his past two starts, Sabathia has yielded 20 hits and 18 runs in only 7 1-3 innings.

White Sox 3, Orioles 1

BALTIMORE – Looks like a one-game suspension was just what Jim Thome needed to put some life back into his bat.

Thome broke a prolonged power drought with a three-run homer and a double, leading the Chicago White Sox past the skidding Baltimore Orioles 3-1 Wednesday night.

Jose Contreras (1-1) pitched seven innings of four-hit ball for the White Sox, who have won nine of 12. He struck out six, walked none and lowered his ERA from 6.17 to 4.34. Scott Linebrink worked the eighth and Bobby Jenks got three straight outs for his sixth save.

Astros 2, Phillies 1

PHILADELPHIA – Roy Oswalt snapped out of an early funk with seven strong innings, Michael Bourn hit a tiebreaking solo homer and the Houston Astros beat the Philadelphia Phillies 2-1 Wednesday night.

Bourn connected off Kyle Kendrick (1-2) in the fifth inning to help beat his former teammates a night after the Phillies scored four runs off closer Jose Valverde to win in the bottom of the ninth.

Oswalt (1-3) finally looked like a three-time All-Star instead of the worst pitcher in the NL. The right-hander gave up one run and five hits to snap a three-game losing skid and beat the Phillies for the sixth straight time. Oswalt came in first or tied for first in the league in losses, runs and hits allowed.

Marlins 6, Braves 5

MIAMI – Mike Jacobs hit his sixth home run and Luis Gonzalez added a two-run pinch-hit homer to help the surprising Florida Marlins beat the struggling Atlanta Braves 6-5 Wednesday night.

Tim Hudson (2-1) lasted only three innings for the Braves, who lost their third in a row and fell to 0-7 in one-run games. They’re 2-7 on the road.

Mark Hendrickson (3-1) won his third start in a row for the Marlins, who are last in the NL in ERA but 9-0 when scoring at least four runs. They lead the NL East despite the lowest payroll in the majors. Florida was nursing a 4-3 lead when Gonzalez homered in the seventh. It was the second pinch-hit homer of his career out of 348 total.

Jacobs, who came into the game tied for the NL lead in home runs, hit a two-out homer off Hudson in the third. It was only the second homer allowed by a Braves starter this year.

Mets 5, Nationals 2

NEW YORK – Carlos Beltran hit his first homer of the season, a three-run shot in a four-run fifth inning, to back John Maine’s solid start and lead the New York Mets past the Washington Nationals 5-2 on Wednesday night.

Jose Reyes also connected for the first time and Ryan Church hit his second home run to help New York hand the anemic Nationals their 11th loss in 12 games. Maine earned his first win with support from a bullpen that spoiled his stellar effort April 10 against the Phillies. After he walked two with two outs in the seventh inning Wednesday, Joe Smith got No. 3 hitter Ryan Zimmerman on a called third strike.

In his previous start, Maine (1-1) took a 3-0 lead into the seventh but Aaron Heilman squandered the lead in the eighth.

Cardinals 5, Brewers 4

ST. LOUIS – Adam Wainwright pitched into the eighth inning and homered Wednesday night, helping the St. Louis Cardinals run their home winning streak to seven with a 5-4 victory over the Milwaukee Brewers.

Albert Pujols contributed with his bat and glove. He hit an early two-run double, then made a leaping catch at first base in the ninth to prevent Milwaukee from tying it.

Rick Ankiel drew an extraordinary 17-pitch walk, Skip Schumaker gave the Cardinals a second homer from an unlikely source and St. Louis matched its longest home winning streak since 2005 at the old Busch Stadium. Cardinals closer Jason Isringhausen took a 5-2 lead into the ninth, but RBI doubles by J.J. Hardy and pinch-hitter Craig Counsell closed the gap with one out. After Pujols ranged to his right to catch Jason Kendall’s liner, Isringhausen held on for his sixth save by retiring Rickie Weeks on a comebacker.

St. Louis is 7-1 at home this season, losing only on opening day. The Cardinals’ overall 11-4 record is tied with Arizona for the best in the majors.