DENVER – Showing the ultimate confidence in his offense, Denver coach Mike Shanahan went for a 2-point conversion with 29 seconds left. Jay Cutler hit rookie Eddie Royal over the middle to give the Denver Broncos a 39-38 win over the stunned San Diego Chargers on Sunday.

The Chargers (0-2) couldn’t believe they lost in the final seconds for the second straight week, with a controversial officiating call helping decide the outcome.

Trailing 38-31, the Broncos (2-0) reached the 1, but on third-and-goal, Cutler reared back to throw. The ball slipped out of his hands, bounced off the grass and into linebacker Tim Dobbins’ hands.

But referee Ed Hochuli blew his whistle, apparently ruling it an incomplete pass. After a review, Hochuli said the Broncos would keep the ball because his whistle had blown the play dead. The Broncos got the ball at the 10, where it hit the grass.

Two plays later, Cutler hit Royal for the TD to make it 38-37.

Instead of going for the tie, Shanahan kept his offense on the field and, 75,000-plus fans at Invesco Field holding their breath, Cutler again found Royal in the end zone.

49ers 33, Seahawks 30, OT

SEATTLE – Joe Nedney shook off a missed field goal as time expired in regulation and kicked a 40-yarder 4:40 into overtime. The loss left the four-time defending division champions 0-2 for the first time since 2002.

San Francisco (1-1) overcame eight sacks of J.T. O’Sullivan to beat the Seahawks for just the third time in 11 games, in the first overtime game of the 19-game series between the two teams.

O’Sullivan was 20-for-31 for 321 yards and one touchdown in the second start of his six-year career.

Giants 41, Rams 13

ST. LOUIS – A 97-yard drive put the New York offense in gear. Another stifling effort from a big-play defense led by Justin Tuck made much of the scoring window dressing in the Giants’ 12th straight away win, including their Super Bowl victory last February.

Eli Manning threw three touchdown passes and the Giants sacked Marc Bulger six times while limiting the Rams to a fluke touchdown.

Colts 18, Vikings 15

MINNEAPOLIS – Taking a beating all afternoon, Peyton Manning peeled himself off the Metrodome turf and gave it right back to the Minnesota defense.

Manning rallied Indianapolis from a 15-0 hole late in the third quarter, moving Adam Vinatieri into position for the winning field goal with 3 seconds left.

Packers 48, Lions 25

DETROIT – Aaron Rodgers threw three touchdown passes in the first four drives of his second start, helping Green Bay build a big lead it needed.

Green Bay led 21-0 midway through the second quarter, but fell behind by a point with 7:41 left after Calvin Johnson caught his second TD in the fourth quarter.

The Packers (2-0) went back ahead with a field goal on the ensuing drive, then turned the game into the rout it had been for much of the day with three straight interceptions.

Raiders 23, Chiefs 8

KANSAS CITY, Mo. – The Raiders, with plenty of help from Kansas City, set aside all their backbiting and turmoil long enough to win a football game.

Rookie Darren McFadden ran for 164 yards and a touchdown and Sebastian Janikowski kicked a team-record 56-yard field goal against an inept Chiefs team that tried three quarterbacks.

Lane Kiffin, amid reports that his job is in jeopardy, won for just the fifth time 18 games as coach of the Raiders (1-1).

Titans 24, Bengals 7

CINCINNATI – With Vince Young not even with the team, the Titans ended a troubling and confusing week by winning in a breeze.

Backup quarterback Kerry Collins threw low, tight passes that stayed on track in Cincinnati’s wind-tunnel of a stadium. Collins threw his first touchdown pass in two years, rookie Chris Johnson ran for 109 yards, and Rob Bironas guided a low, curving kick between gyrating uprights for a 34-yard field goal.

Bills 20, Jaguars 16

JACKSONVILLE, Fla. – Trent Edwards was good early and even better late, doing just enough to lead the Bills (2-0) to their best start in five years.

Edwards completed his first 10 attempts and threw a perfect touchdown pass to James Hardy late in the fourth quarter.

Edwards finished 20-of-25 for 239 yards, Marshawn Lynch ran for 59 yards and a score, and Buffalo’s defense held Jacksonville in check most of the day.

The Jaguars (0-2) are off to their worst start since 2003.

Panthers 20, Bears 17

CHARLOTTE, N.C – After watching the Bears build a big lead behind a stout defense and a rookie running back, the Panthers used the same combination to stage a late comeback for an unlikely 2-0 start.

Jonathan Stewart rushed for all but one of his 77 yards in the second half and scored two touchdowns, including the go-ahead TD late in the fourth quarter, and the Panthers stopped the Bears (1-1) on fourth-and-1 with under 2 minutes left.

Redskins 29, Saints 24

LANDOVER, Md. – Jason Campbell hit Santana Moss for a 67-yard touchdown pass that won the game. Campbell and new Washington Redskins coach Jim Zorn’s West Coast offense succeeded in Week 2 as spectacularly as it failed in Week 1. Campbell went from uncomfortable to prolific, completing 24 of 36 passes for 321 yards.

The big play came with 3:29 left. Campbell avoided the rush, stepped forward and hit Moss in stride, the receiver one step ahead of cornerback Tracy Porter. The completion was the longest of Campbell’s career.

Cardinals 31, Dolphins 10

GLENDALE, Ariz. – Kurt Warner looked like he did in his MVP days, Anquan Boldin certainly wasn’t sulking over contract woes, and Larry Fitzgerald caught almost everything thrown his way.

The result was a rout that has the Cardinals 2-0 for the first time in 17 years.

Warner completed 19 of 24 passes for 361 yards and three touchdowns with no interceptions. Boldin caught all three scores, a career high.

Buccaneers 24, Falcons 9

TAMPA, Fla. – Rookie Matt Ryan was intercepted twice in the first half and Tampa Bay’s Brian Griese turned the miscues into a touchdown and field goal.

A week after beating Detroit in his pro debut, Ryan threw incompletions on his first nine passes before settling down to keep Atlanta (1-1) in the game with three field goal drives that trimmed a 17-point deficit to eight with 5 minutes to go.

The Bucs (1-1) ended any hopes the third pick in this year’s draft would finish an improbable comeback when Earnest Graham broke a tackle in the backfield and barreled around right end and up the sideline on a 68-yard TD run.

Ryan completed 13 of 33 passes for 158 yards. Aqib Talib’s interception on Atlanta’s third play set up Griese’s 5-yard TD throw to John Gilmore and Sabby Piscitelli’s pick and 17-yard return positioned the Bucs for Matt Bryant’s 33-yard field goal that made it 17-0 late in the second quarter.