1. Will Netflix flex its newfound muscle?

As the streaming service zooms past the 100 million-subscriber milestone, it will aim to stand tall alongside network rivals. Such original series as “DreamWorks Voltron: Legendary Defender,” “Castlevania” and “Buddy Thunderstruck” promise top panelists, but expect the most noise to be directed toward performers from the big team-up “Marvel’s The Defenders” (debuting Aug. 18) and the smash “Stranger Things” (ahead of its second-season Halloween return).

Elsewhere, Netflix Films will tease David Ayer’s “Bright” and the manga-adapted “Death Note.”

Meanwhile, another streaming service, Amazon Studios, will roll out panels for such new original projects as “Emily the Strange,” “Danger and Eggs” (with SNL’s Aidy Bryant) and “The Tick” (debuting Aug. 25), the last of which will include an off-site fan experience that simulates being on set. (Disclaimer: Amazon founder Jeffrey P. Bezos owns The Washington Post. But then, you knew that.)

2. Who will reign between the big-screen behemoths: DC or Marvel?

The biggest headlines are typically sparked by the Hollywood superheroes from the Big 2. And this year, DC has something to crow about. Expect thunderous applause to greet Gal Gadot as she basks in a Hall H victory lap for the still-soaring “Wonder Woman” (which within days will become the year’s second-biggest film domestically). Gadot will be on hand alongside Ben Affleck, Jason Momoa and friends to get fans cheering for November’s long-awaited “Justice League” from Zack Snyder and Joss Whedon.

Marvel, meanwhile, is scheduled to have on hand Chadwick Boseman for next year’s hotly anticipated “Black Panther,” as well as its usual squad of veteran superhero actors – plus new Spider-Man Tom Holland – to trumpet the Avengers’ “Infinity War.” After last weekend’s D23 expo, Team Marvel has this drill down, as led by studio chief Kevin Feige.

The bottom line beyond the San Diego Convention Center: Which studio will treat the world to more tantalizing trailer footage?

3. Who will get more anniversary love: Eisner or Kirby?

Twin monoliths without whom the comics industry would not be what it is – Will Eisner and Jack “King” Kirby – will receive special celebrations; each would have turned 100 this year. As Comic-Con (which hosts the annual Eisner Awards) pays rightful tribute to each giant, the centennial sessions will include a spotlight with Mike Royer (Kirby’s “favorite inker”); “Why Will Eisner Still Matters at 100? (with ex-DC Comics president Paul Levitz and Eisner Awards administrator Jackie Estrada, among others); and “Will Eisner: Portrait of a Sequential Artist” (with historian Danny Fingeroth).

4. Where lies the Trump Effect?

This is the first Comic-Con under President Trump, so expect some first-wave humor to be trumpeted by early comic responders. Two of the more notable creators are Shannon Wheeler, who is drawing the forthcoming Top Shelf book “Sh*t My President Says” (based on the commander in chief’s tweets) and Robert Sikoryak’s “The Unquotable Trump.” A Thursday panel will pose the question: “Can satire keep up with reality?”

5. Will the fan-Force be as strong as ever?

Ever since early Star Wars sketches were teased at Comic-Con more than four decades ago, George Lucas’s world-building has held a central presence, from beeping collectibles to cosplay contests to the comic books themselves. With “The Last Jedi” due in December – and with Carrie Fisher’s recent passing and “Jedi” appearance on so many minds – anticipate that Star Wars fandom will express itself in inspiring new ways, from the “dysfunctional family” panel to Princess Leia tributes to sessions on the orchestrated sound and fury of Star Wars.

6. Doctor Who?

With the announcement this week that Jodie Whittaker will be the new star of “Doctor Who,” the legendary BBC series will be in the center spotlight as it bids adieu to star Peter Capaldi and trots out showrunner Steven Moffat during its big Hall H session Sunday. The big question: Will Whittaker, the show’s 13th Time Lord and the first female lead, make an appearance? Because the hall would go wild.