Baltimore’s Gunnar Henderson is congratulated by Austin Hays after his two-run home run in the 10th inning against the Boston Red Sox on Thursday in Boston. Charles Krupa/Associated Press

BOSTON — Colton Cowser hit the first two homers of his career, including a three-run shot in the 10th inning, and the Baltimore Orioles rallied past the Boston Red Sox 9-4 on Thursday night to complete a three-game sweep of their AL East rivals.

Gunnar Henderson opened the Orioles’ six-run 10th with a two-run homer against Isaiah Campbell (0-1), scoring automatic runner Jackson Holliday.

The 20-year-old Holliday, baseball’s top-rated prospect who made his big league debut a night earlier, scored two runs but went 0 for 4 for the second straight game.

Cowser, another Orioles prospect who struggled during a brief stint in the majors last season, drove in 10 runs in the series.

A night after the Orioles rallied from a 5-0 deficit to win 7-5, they fell behind 2-0 before coming back, thanks in part to some shaky defense by the Red Sox.

Boston led 2-1 when Holliday reached on an error by third baseman Pablo Reyes leading off the eighth. With one out, Adley Rutschman hit what appeared to be an inning-ending double-play grounder, but the Orioles challenged the call, and after a review, Holliday was ruled safe at second because shortstop David Hamilton missed the bag while making the turn.

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Reliever Greg Weissert came in, and Anthony Santander hooked his first pitch around the foul pole in right for a two-run homer that made it 3-2.

Pinch-hitter Connor Wong tied it with two outs in the eighth with a homer over the Green Monster off Danny Coulombe. It was Wong’s first homer of the season and first career pinch homer.

Craig Kimbrel (2-0) worked a scoreless ninth.

Orioles starter Grayson Rodriguez worked 5 2/3 innings, allowing both of his runs in the first.

Garrett Whitlock lasted five innings for Boston and gave up Cowser’s first homer, a solo shot.

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