TORONTO (AP) – Daisuke Matsuzaka won his third straight decision, Manny Ramirez hit his 476th career home run and the Boston Red Sox beat Toronto 9-3 Wednesday night to hand the Blue Jays their eighth straight loss.

David Ortiz homered and tied a career high with four hits for Boston, which has won six of its last seven.

Mike Lowell and Julio Lugo also cleared the fence as the Red Sox hit four homers for the second consecutive game.

Matsuzaka (4-2), who allowed a season-high seven runs in his last start, was much more effective against Toronto. He struck out eight in seven innings, allowing just one run and five hits.

The matchup between Matsuzaka and Toronto’s Tomo Ohka was just the fourth time in major league history that two Japanese starters have faced off.

The last time it happened was June 19, 2002, when Ohka, then with Montreal, beat Kansas City’s Mac Suzuki.

Ohka (2-4) got the loss in this one, allowing three runs and six hits over 4 2-3 innings. He walked five, one intentional, and struck out two.

Ramirez put the Red Sox in front with a run-scoring groundout in the first, and sloppy defense from Ohka led to two more Boston runs in the second.

With Eric Hinske at first after a leadoff walk, Dustin Pedroia bunted up the first-base line.

Ohka tried to push the ball to first but it rolled past the bag and down the line, allowing both runners to move up.

Lugo followed with a run-scoring groundout and Pedroia scored on Ortiz’s opposite-field double.

Boston added three more in the sixth against reliever Scott Downs, who had not given up a run in 9 1-3 innings over 15 appearances.

Pedroia led off with a single and scored on Lugo’s homer, his second. Two outs later, Ramirez homered into the second deck in left, his sixth.

Ortiz hit a two-run homer off Josh Towers in the eighth, his ninth, and Lowell added his sixth homer in the ninth.

Lyle Overbay’s solo homer in the sixth was all Toronto could manage against Matsuzaka. Overbay added another home run in the ninth, his sixth, off Joel Pineiro.

It’s Toronto’s first multihomer game of the season and the fifth of Overbay’s career.

The Blue Jays remain mired in their worst stretch since a nine-game losing streak in 2002.

Notes: Boston’s Kevin Youkilis (sore left leg) was a late scratch. He was replaced by Hinske. … Suzuki was the loser in all three previous matchups of Japanese pitchers, losing to New York’s Hideki Irabu on May 7, 1999, and to Detroit’s Hideo Nomo on July 2, 2000. … It was Ortiz’s 10th four-hit game and his first since July 29 against the Los Angeles Angels.