Boston’s 6-1 loss to Toronto on Wednesday guaranteed the team will not make the playoffs for the fourth time in five seasons.

The Red Sox, who had won four in a row, needed to win their final four games and get help from opponents in the American League wild-card race.

Trailing 3-0, Boston scores two in the seventh, one in the eighth and three in the 10th.

Tanner Houck carries a perfect game into the fifth in Boston’s 4-1 win.

Jansen is a free agent after the season and has likely pitched his last game with the Red Sox.

Devers was placed on the injured list Saturday with left shoulder inflammation.

Casas drives in seven runs in Boston’s 8-1 victory in the first game, while Romy Gonzalez hits a three-run home run in an 9-3 win in Game 2.

Refsnyder will miss the rest of the season with a right forearm strain.

Zack Littell allows one hit over seven innings and Nick Sogard has the only hit for Boston.