CHICAGO -Khalil Greene singled home the go-ahead run in the 11th inning and the San Diego Padres beat the Chicago Cubs 5-4 to move within a game of the NL wild-card lead.

The Padres tied the game at 4 in the eighth on Brian Giles’ RBI single off Mike Remlinger after Nomar Garciaparra hit a two-run homer in the seventh to give Chicago the lead.

The game was twice delayed by rain for a total of 78 minutes on a chilly day at Wrigley Field, where the temperature at the start was just 60 degrees.

Phil Nevin, who didn’t start because of the flu, singled to start the 11th, moved to second on a sacrifice and then to third on a bunt single by Ramon Hernandez.

With two outs, Greene hit an 0-2 pitch from Ryan Dempster (0-1) through the hole into left field to put the Padres in front.

Ricky Stone (2-2) pitched a scoreless 10th for the win. Trevor Hoffman got three outs for his 31st save, retiring Moises Alou on a popup with a runner on third to end it.

Mets 2, Astros 1

NEW YORK – Andy Pettitte had another frustrating outing in his return to New York.

Pitching across town from the ballpark where he became a star during nine seasons with the Yankees, he allowed just one run but struggled with his control and didn’t make it out of the sixth inning. The Mets went on to beat Pettitte’s Houston Astros 2-1 behind Joe McEwing’s go-ahead single in the seventh off former-Met David Weathers.

Marlins 8, Cardinals 2

MIAMI – A.J. Burnett pitched seven innings, Damion Easley drove in three runs and the Florida Marlins took advantage of sloppy defense by St. Louis to win 8-2, ending the Cardinals’ seven-game winning streak.

Braves 4, Brewers 2

ATLANTA – Jaret Wright won his ninth straight decision and J.D. Drew hit a go-ahead homer to help the Atlanta Braves beat Ben Sheets and the Milwaukee Brewers 4-2.

Expos 7, D-backs 5

MONTREAL – Tony Batista hit his 20th homer and drove in four runs, leading the Montreal Expos over Arizona 7-5 to complete a three-game sweep of the Diamondbacks.

The Expos won their fifth straight game and sent Arizona to its seventh loss in a row.

Reds 6, Dodgers 5

CINCINNATI – D’Angelo Jimenez singled in the go-ahead run in the eighth inning and the Cincinnati Reds rallied past the Los Angeles Dodgers 6-5 to avoid a three-game sweep.

Giants 7, Pirates 0

PITTSBURGH – Jason Schmidt pitched a four-hitter with 11 strikeouts for his NL-leading 15th win, and the San Francisco Giants defeated the Pittsburgh Pirates 7-0.

Rockies 3, Phillies 1

PHILADELPHIA -Shawn Estes allowed one run in six innings and Royce Clayton hit a two-run homer to lead the Colorado Rockies to a 3-1 victory over the Philadelphia Phillies.

The Rockies took three of four in the series, keeping the Phillies 3 games behind Chicago in the NL wild-card race.

After hitting a season-high six home runs, the Phillies were stymied by Estes (13-4). The left-hander scattered four hits and struck out three to win his fifth straight decision.

Tim Harikkala pitched two perfect innings, and Shawn Chacon allowed a hit but struck out the side in the ninth for his 29th save in 37 chances, completing the five-hitter.

Clayton gave the Rockies a 2-0 lead in the third inning with his eighth homer, a two-run shot to left off Corey Lidle (7-11) in his Phillies debut.

Lidle was traded by Cincinnati on Monday, a day after he beat the Rockies, though he allowed nine hits and three runs in that start.

Lidle struggled with his control most of Thursday’s game, walking three and giving up three hits in five innings on three-days rest.

Orioles 6, Angels 1

ANAHEIM, Calif. – Melvin Mora homered and drove in three runs, Rodrigo Lopez pitched seven strong innings and the Baltimore Orioles beat the Anaheim Angels 6-1.

The victory was Baltimore’s ninth in 10 games, and ended Bartolo Colon’s six-game winning streak.

White Sox 3, Royals 2

CHICAGO – Carl Everett and Ross Gload homered, and Freddy Garcia pitched six strong innings to lead the Chicago White Sox to a 3-2 win over the Kansas City Royals.

Tigers 5, Athletics 3

OAKLAND, Calif. – Rondell White hit a tiebreaking homer in the sixth inning, Craig Monroe connected two batters later and the Detroit Tigers beat the Oakland Athletics 5-3.

Twins 6, Mariners 3

SEATTLE – Justin Morneau hit two home runs to awaken Minnesota’s offense, and the Twins snapped a four-game losing streak with a 6-3 win over the Seattle Mariners.

Indians 6, Blue Jays 2

CLEVELAND – Pinch-hitter Ben Broussard hit his second grand slam in four days, sending the Cleveland Indians to a 6-2 victory over the Toronto Blue Jays .