Prime-time viewership numbers compiled by Nielsen Media Research for Sept. 19-25. An “X” in parentheses denotes a season debut or one-time-only presentation.

1. (1) “CSI: Crime Scene Investigation,” CBS, 29.0 million viewers.

2. (2) “Desperate Housewives,” ABC, 28.4 million viewers.

3. (3) “Lost,” ABC, 23.5 million viewers.

4. (X) “Criminal Minds,” CBS, 19.6 million viewers.

5. (4) “CSI: Miami,” CBS, 19.2 million viewers.

6. (5) “Grey’s Anatomy,” ABC, 19.0 million viewers.

7. (9) “Survivor: Guatemala,” CBS, 17.0 million viewers.

8. (8) “Law & Order: SVU,” NBC, 16.8 million viewers.

9. (10) “Invasion,” ABC, 16.4 million viewers.

10. (12) “Extreme Makeover: Home Edition,” ABC, 16.4 million viewers.