HOUSTON – Rookie Hunter Pence homered for the second straight game and the Houston Astros beat the San Francisco Giants 2-1 Wednesday night for their fourth straight win.

The win gives Houston its first home series win over the Giants since 1999 and breaks a streak of five consecutive series losses to San Francisco.

Pence put Houston up 2-1 with a solo homer that bounced off the train tracks above the left-field wall in the fourth inning. He hit a tying two-run drive in the eighth inning of Tuesday’s 6-5, 10-inning win.

Pence, who was called up on April 27 to boost the offense, is 7-for-7 in this series. He had singles in the second, sixth and eighth innings Wednesday and has four home runs and 15 RBIs this season.

Giants slugger Barry Bonds was 1-for-3 with a single and a walk. He hasn’t hit a homer since May 8 and remains 10 away from tying Hank Aaron’s career record of 755. His drought at Minute Maid Park stretches to opening day of 2004.

Fellow rookie Chris Sampson (4-3), who was back with Houston after missing Tuesday’s game for the birth of his first child, allowed one runs and seven hits in six innings. He walked one and struck out three.

Dan Wheeler pitched a perfect ninth for his ninth save in 10 tries.

Rookie Fred Lewis tripled and scored on Ryan Klesko’s double to give the Giants a 1-0 lead in the first inning. Sampson then walked Bonds before getting Ray Durham to ground into an inning-ending double play.

Sampson retired 11 of the next 12 batters. He was helped by some nifty fielding during that stretch that included a leaping catch by third baseman Mark Loretta and Lance Berkman’s sliding grab of a hard-hit grounder to first.

Loretta singled in a run in the third to tie it at 1.

Giants starter Noah Lowry (4-4) pitched his first complete game of the season and first since Aug. 21. He allowed eight hits and two runs, struck out three and walked four. It was the seventh time in his first eight starts that he worked into at least the seventh inning.

Former closer Brad Lidge pitched a perfect seventh for Houston and lefty Trever Miller retired the Giants in order in the eighth.

Notes: Randy Winn had two hits for the Giants to extend his hitting streak to a career-high 15 games. … Lowry has a 3-1 career mark against the Astros. … Houston’s Carlos Lee was 0-for-4, a day after hitting two home runs.

AP-ES-05-16-07 2241EDT