• Deaths: 45 in Mexico and two in the U.S., both in Texas. One of those who died in the U.S. was a toddler from Mexico. Canadian officials say an Alberta woman in her 30s with swine flu died April 28, but she had underlying medical conditions and it’s unclear the disease played a role in her death.

• Confirmed cases: More than 3,100 worldwide in 28 countries, including more than 1,100 in Mexico, at least 1,639 in the United States and 214 in Canada.

• Mexico’s U.N. envoy says nations need common rules for responding to flu outbreaks to prevent discrimination and unfair trade restrictions; says Mexicans unfairly singled out.

• WHO says up to 2 billion people could be infected by swine flu if the outbreak turns into a pandemic over months or years. But WHO flu chief Keiji Fukuda says it’s too early to tell how widespread or severe the outbreak will become.

• Hong Kong lifts its weeklong quarantine on a downtown hotel where a Mexican swine flu patient stayed, releasing some 280 guests and employees who had been isolated in the building.

• Mexican swine flu patient who prompted a quarantine at Hong Kong’s Metropark Hotel is released from hospital after a weeklong stay.

• High schools, universities, dance halls, movie theaters and bars have reopened across Mexico. Primary schools will reopen next week.

• The WHO reports two new human cases of bird flu on Wednesday. One patient is recovering in Egypt, while another died in Vietnam – a reminder that the H5N1 virus is far from gone.

• CDC says only about 10 percent of Americans with swine flu are believed to have gotten it during trips to Mexico. Over the weekend, the agency said about a third of the U.S. cases were people who had been to Mexico, where the outbreak began.

• Diplomats and officials say WHO intends to shorten its annual meeting in Geneva later this month because health ministries around the world are busy with the outbreak.