BOSTON (AP) — Clay Buchholz pitched seven innings of three-hit ball, and Dustin Pedroia hit two of Boston’s season-high six homers to lead the Red Sox to a 10-0 victory over the Baltimore Orioles on Tuesday night.

David Ortiz homered in the seventh inning, his 269th as a designated hitter. That tied Frank Thomas for the most all-time by a DH.

Kevin Youkilis, J.D. Drew and Alex Gonzalez also homered for the Red Sox, whose first five hits were homers as they opened an 8-0 lead after three innings and improved to 12-2 against Baltimore this year. For Pedroia, the reigning AL MVP, it was the first two-homer game of his career.

Michael Bowden got the last six outs to finish off the combined five-hitter.

The offensive outburst allowed Buchholz (5-3) to work with ease. He retired the first 10 batters, struck out five and walked one to improve to 4-0 over his last five starts.

David Hernandez (4-7) lasted 2 2-3 innings, allowing six runs on four homers while walking two and striking out three. He is 0-3 in his last five starts.

Jacoby Ellsbury drew a leadoff walk, then Pedroia made it 2-0 with a homer off the top of a billboard above the Green Monster. Gonzalez made it 3-0 in the second when he hit his over the same sign. Pedroia led off the third with another homer, this one into the Monster Seats.

After Ortiz walked to chase Hernandez, callup Chris Lambert walked Jason Bay and gave up a three-run shot to Drew.

Ortiz’s homer in the seventh made it 10-0.

NOTES: Drew reached 20 homers for the fourth time in his career, the first since he was with the Dodgers in 2006. … Ortiz, who homered off right-hander Bob McCrory, has 312 total. … Baltimore is 4-21 on the road against the AL East. … The Orioles placed OF Adam Jones on the 15-day DL with a sprained left ankle, retroactive to Sept. 2. Baltimore recalled McCrory, Lambert and LHP Chris Waters from Triple-A Norfolk, and selected the contracts of INF Justin Turner and C Guillermo Rodriguez. … The Red Sox activated SS Jed Lowrie from the 15-day DL and recalled C Dusty Brown from Triple-A Pawtucket. Boston signed SS Jose Iglesias to a four-year contract, beginning in 2010.

Red Sox activate SS Lowrie from DL

BOSTON (AP) – The Boston Red Sox have activated shortstop Jed Lowrie from the 15-day disabled list. The team also recalled catcher Dusty Brown from Triple-A Pawtucket.

Also, the Red Sox signed shortstop Jose Iglesias to a four-year contract, beginning in 2010.

Lowrie has been on the disabled list since Aug. 8 with a sore left wrist.

Brown is making his second stop in Boston.

Iglesias is expected to play for the Mesa Solar Sox in the Arizona Fall League beginning in October.

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