No. 5 Bangor (2-6) at No. 4 Edward Little (3-5)

Friday, 7 p.m.

Red Eddies trying to back up their huge comeback win at Cameron Stadium in September. Rams seek revenge after giving away two-touchdown lead.

No. 6 Lewiston (2-6) at No. 3 Cheverus (5-3)

Saturday, 12:30 p.m.

Stags won 68-16 the first time around. Freshman RB Tre Fletcher emerged in that game and has proven difficult for opponents to stop.

Class B

No. 5 Cony (4-4) at No. 4 Mt. Blue (5-3)

Friday, 7 p.m.

Rams didn’t have Reid Shostak available to make plays in 20-6 Week 1 loss. Cougars’ close losses to Brewer and Skowhegan left them with tough QF matchup.

No. 7 Greely (3-5) at No. 2 Leavitt (6-2)

Friday, 7 p.m.

Hornets shouldn’t have any trouble staying motivated for this one. They only won 20-14 over the Rangers in a physical game three weeks ago, and Greely knocked off No. 1 Falmouth to clinch spot.

Class C

No. 8 Mountain Valley (2-6) at No. 1 Yarmouth (8-0)

Friday, 7 p.m.

Falcons trailed only 13-7 in regular-season matchup before Clippers made defensive stop and rolled from there.

No. 7 Gray-New Gloucester (4-4) at No. 2 Cape Elizabeth (6-2)

Friday, 7 p.m.

Capers’ 7-0 victory in Gray on an interception return by Ben Ekedahl was one of the games of the year in the Campbell Conference.

No. 6 Poland (4-4) at No 3 Wells (6-2)

Friday, 7 p.m.

Knights finished at .500 mark for the only the second time in 13 seasons of football. Teams didn’t meet this season, but Wells rolled 55-27 in 2014 playoffs.

No. 5 Spruce Mountain (4-4) at No. 4 Fryeburg (5-3)

Saturday, 1 p.m.

Raiders carry four-game winning streak into first home playoff game in school history. FA beat Spruce in the 2012 regular-season finale to deny Phoenix a playoff berth.

Class D

No. 7 Old Orchard Beach (2-5) at No. 2 Dirigo (6-2)

Friday, 7 p.m.

To call the Cougars a longstanding playoff nemesis for the Seagulls (football, basketball, baseball) would be a gross understatement.

No. 5 Maranacook (4-3) at No. 4 Winthrop/Monmouth (4-3)

Friday, 7 p.m.

Black Bears know they let one get away during the regular season in 17-13, last-minute loss. Ramblers know they let No. 2 seed get away with stunning loss to Boothbay.

No. 8 Traip (2-5) at No. 1 Oak Hill (7-0)

Saturday, 12:30 p.m.

Never easy to play the same team two consecutive weeks, but Raiders will try to take care of business after 32-6 win in Kittery.

No. 6 Boothbay (2-5) at No. 3 Lisbon (5-2)

Saturday, 1 p.m.

Greyhounds will be on high alert. Regular-season game was only 19-0, and Seahawks clearly playing their best at season’s end.