MINNEAPOLIS – Not even a painful blister on his pitching hand could derail Johan Santana. He’s just been unbeatable at the Metrodome.

Santana held the White Sox offense to one run in seven innings and Michael Cuddyer had two hits and two RBIs in Minnesota’s 7-3 victory over the White Sox on Sunday, cutting Chicago’s lead to one game in the AL wild-card race.

Santana (15-5) hasn’t lost at the Metrodome in 20 starts, dating to Aug. 6, 2005. He is 13-0 with a 2.03 ERA during that stretch.

White Sox starter Javier Vazquez (11-8) gave up five runs, four earned, on seven hits in seven innings. He entered the game leading the majors in run support with 8.13 per game, but knew he wouldn’t have that luxury facing Santana, who is making a strong bid for his second AL Cy Young award in three years.

Angels 3, Mariners 2

ANAHEIM, Calif. – Chone Figgins singled home the winning run in the ninth inning and the Angels sent the Mariners to their 11th straight loss.

Seattle’s losing streak is its longest since September 1992, when the Mariners dropped a club-record 14 straight. All 11 losses have come on this road trip, the first winless trip of 11 or more games in the franchise’s 30-year history.

Seattle closer J.J. Putz (2-1) came in with two out in the eighth after reliever Rafael Soriano gave up a walk to Orlando Cabrera and a single to Vladimir Guerrero. Garret Anderson, the Angels’ career RBI leader, greeted Putz with an opposite-field single to left that brought home Cabrera to tie it at 2.

Indians 9, Devil Rays 4

ST. PETERSBURG, Fla. – Jhonny Peralta hit his first career grand slam during a five-run sixth and Travis Hafner homered in his third straight game to help Cleveland beat Tampa Bay.

Cleveland loaded the bases with no outs in the sixth when reliever Brian Meadows intentionally walked Hafner with runners on first and third. Ryan Garko had an RBI single before Peralta’s grand slam made it 9-2.

Jake Westbrook (10-8) gave up three runs and eight hits in seven innings. He struck out four and walked two.

Blue Jays 9, Orioles 2

BALTIMORE – Roy Halladay retired the first 16 batters in earning his major league-leading 16th win, and the Blue Jays hit three homers in a rout of the Orioles.

Halladay (16-3) allowed two runs, four hits and a walk in seven innings, striking out two. The right-hander was perfect until rookie Brandon Fahey grounded a single up the middle with one out in the sixth.

Troy Glaus, Bengie Molina and Reed Johnson homered for the Blue Jays.

Athletics 6, Royals 4

KANSAS CITY, Mo. – Nick Swisher hit a two-run home run and Kirk Saarloos survived six shaky innings for his third straight victory, leading the surging Athletics past Kansas City.

The AL-West leading A’s, who put closer Huston Street on the 15-day disabled list earlier Sunday, got a split of the four-game series after losing both ends of a doubleheader on Friday. They’ve won eight of their last 10 and their August record of 14-4 is second-best in the majors behind only the Los Angeles Dodgers.

Rangers 7, Tigers 6

DETROIT – Hank Blalock hit a tiebreaking single in the sixth, Gary Matthews throw to the plate kept the lead the next inning and the Rangers held on after overcoming a six-run deficit to beat the Tigers.

Josh Rupe and three more relievers slowed Detroit down after it scored six runs in the second inning against John Koronka.

The Tigers have lost nine of 12 games, watching their 10-game lead in the AL Central shrink.

They begin a four-game series Monday at home against the Chicago White Sox.

Joaquin Benoit (1-1) got the win and Akinori Otsuka pitched the ninth for his 26th save in 29 chances.

Jason Grilli (1-2) suffered the loss.