NEW YORK – Adam Eaton pitched seven sharp innings, Phil Nevin hit a three-run homer and the San Diego Padres capitalized on Mike Mussina’s early departure to beat the New York Yankees 10-2 Friday night.

Mussina left after just three innings because of tightness in his right groin. He came out as a precaution, the Yankees said. His injury occurred just two days after teammate Kevin Brown left his start against Colorado with a strained back.

The Yankees lost their first interleague game since being no-hit by six Houston pitchers exactly a year ago. They had won 13 straight interleague matchups and four in a row overall.

Mussina struck out four of his first six batters and seemed to be on his way to another stellar start before the injury.

After Alex Rodriguez gave the Yankees an early lead with a solo homer to right in the first inning, the Padres scored an unusual run on an infield hit, a stolen base and two errors.

Kerry Robinson got the first hit off Mussina with one out in the third and stole second. He advanced to third when catcher Jorge Posada’s throw hit him sliding into the bag. Robinson then scored after left fielder Hideki Matsui’s throw back into the infield hit second base and bounced back into the outfield.

Tigers 8, Marlins 4

DETROIT – Ivan Rodriguez homered in his first game against his former team, helping the Detroit Tigers beat the Florida Marlins 8-4 Friday night.

Dmitri Young hit a three-run shot for his first homer of the year, and Carlos Guillen added a two-run drive for the Tigers.

Rodriguez, the star catcher who helped Florida to a surprising World Series title last October, went 2-for-4 with a single.

Gary Knotts (4-1), another former Marlin, got the win. He allowed four runs on five hits and three walks in 6 1-3 innings, helping Detroit improve to 3-1 in interleague play.

Former Tigers farmhand Tommy Phelps (1-1) took the loss, giving up six runs and six in three-plus innings.

The first five batters of the inning scored on homers by Young and Guillen, who set a career high with his 10th of the season.

Diamondbacks 3, Blue Jays 2

TORONTO – Danny Bautista hit a go-ahead single in the ninth inning and the Arizona Diamondbacks rallied for a 3-2 victory over the Toronto Blue Jays on Friday night.

Randy Choate (1-0) got two outs for the win. Jose Valverde got two outs for his seventh save.

Toronto starter Pat Hentgen pitched seven scoreless innings but wound up with nothing to show for it.

Arizona starter Steve Sparks allowed just two runs – one earned – and eight hits in 7 1-3 innings.

The knuckleballer retired 11 straight batters before Howie Clark and Frank Catalanotto chased him with consecutive singles in the eighth.

Devil Rays 8, Rockies 7

ST. PETERSBURG, Fla. – Rey Sanchez hit an inside-the-park homer in the 10th inning to lead the Tampa Bay Devil Rays to an 8-7 victory over the Colorado Rockies on Friday night.

Sanchez hit a liner to right field off Shawn Chacon (0-3) that went all the way to the wall after Jeromy Burnitz missed a shoestring catch attempt. Center fielder Choo Freeman backed up the play and retrieved the ball, but Sanchez was already headed home with the winning run.

Jose Cruz Jr. and Robert Fick homered for the Devil Rays, who are 14-6 in their last 20 games – the best stretch in team history.

The victory moved Tampa Bay manager Lou Piniella into a tie for 22nd place all-time with Jimmy Dykes with 1,406 wins.

Braves 6, White Sox 4

CHICAGO – Jaret Wright pitched two-hit ball for seven scoreless innings and Eli Marrero hit a three-run double in the Atlanta Braves’ 6-4 win over the Chicago White Sox on Friday night.

The White Sox rallied for four runs against John Smoltz in the ninth on Carlos Lee’s RBI double and Jose Valentin’s three-run homer. But Smoltz struck out pinch-hitter Timo Perez with a runner on to end it.

Wright (5-5) won his third straight decision and struck out a season-high eight. The right-hander fanned six of nine at one point and set down 14 of 15 batters before leaving the game. He walked two and was pulled after 104 pitches.

Chris Reitsma worked a hitless eighth before giving way to Smoltz.

s the fourth consecutive win for the Braves over the White Sox. Atlanta swept a three-game series last year.

Brewers 9, Astros 3

MILWAUKEE – Scott Podsednik hit a three-run homer and an RBI double to back a solid outing by Doug Davis in the Milwaukee Brewers’ 9-3 victory over the Houston Astros on Friday night.

Geoff Jenkins and Junior Spivey also homered for the Brewers, who have beaten Tim Redding three times this season.

Jeff Kent extended his career-best hitting streak to 25 games, a franchise record.

Phillies 11, Twins 6

MINNEAPOLIS – Ricky Ledee’s three-run homer, his second of the night, capped a five-run ninth inning for the Philadelphia Phillies in an 11-6 victory that ended the Minnesota Twins’ four-game winning streak Friday night.

Lew Ford’s two-run homer in the seventh for the Twins tied it at 6, but Jim Thome gave the Phillies the lead back with a two-run double in the ninth against J.C. Romero.

Ledee, who hit a two-run homer in the fourth, then broke the game open with a three-run shot in just his seventh start of the season. He tied a career high with five RBIs and Philadelphia scored 11 runs or more for the third straight time.

Cardinals 12, Rangers 7

ARLINGTON, Texas – Albert Pujols returned from a hamstring injury and drove in a run, and John Mabry homered and had five RBIs in the St. Louis Cardinals’ 12-7 victory over the Texas Rangers on Friday night.

Jeff Suppan (6-5) gave up four runs, two earned, in six innings to improve to 5-0 lifetime against Texas.

Brad Fullmer, Laynce Nix and Alfonso Soriano hit solo homers for Texas, whose three-game winning streak ended.

Pujols finished 1-for-5, including an RBI single in the third.

Indians 6, Reds 5

CLEVELAND – Pinch-hitter Lou Merloni drew a bases-loaded walk in the 11th inning, and the Cleveland Indians rallied for a 6-5 win over the Cincinnati Reds on Friday night.

Casey Blake singled with two outs in the 11th and went to second on a wild pitch. Travis Hafner and Ronnie Belliard were walked by Norton to load the bases for Merloni, who worked the count to 3-2 before taking a high pitch.

David Riske (3-2) stuck out five in two innings as the Indians won the opener of the three-game interleague series against their NL in-state rivals.

Royals 7, Mets 5

KANSAS CITY, Mo. – Matt Stairs doubled and tripled to help Darrell May avoid becoming the majors’ first nine-game loser, and the Kansas City Royals beat the slumping New York Mets 7-5 on Friday night.

May (3-8), one of only two pitchers with eight losses, gave up a double to Gerald Williams on the first pitch of the game. The veteran left-hander allowed 11 hits and five runs in six innings, with five strikeouts. He won for just the second time in 11 decisions.