GLENDALE, Ariz. -Mistakes made the difference in Arizona, and the Cardinals beat another AFC North team.

Arizona turned three of Cleveland’s four turnovers into touchdowns, Edgerrin James topped 100 yards rushing for only the second time this season and the Cardinals held on to beat the Browns 27-21 on Sunday.

Kurt Warner threw two touchdown passes and Neil Rackers kicked a pair of late field goals as Arizona (6-6) improved to 3-1 against the AFC North. The Cardinals’ other victories were over Pittsburgh and Cincinnati.

Derek Anderson had two touchdown tosses, but was intercepted twice and fumbled the ball away once for the Browns (7-5), who lost for just the second time in seven games. Two of the turnovers came on Cleveland’s first two possessions and led to touchdowns that put the Cardinals ahead 14-0.

Rod Hood returned an interception 71 yards for a touchdown for the first score. On the next possession, Anderson’s fumbled snap led to a second score by Arizona.

The Browns got a controversial 67-yard touchdown pass from Anderson to Braylon Edwards, and a 2-point conversion, to cut the lead to 21-18 on the final play of the third quarter.

But a pair of late personal foul penalties damaged the Browns’ chances for a final comeback.

Still, Cleveland drove to the Arizona 37 in the final seconds.

On the last play, Anderson threw to the left side of the end zone for Kellen Winslow. The big tight end caught it, but was ruled out of bounds. Cleveland challenged that he was forced out, but the ruling on the field was upheld.

The Cardinals, already playing without Larry Fitzgerald with a groin injury, lost Anquan Boldin, their other standout receiver, with an injured left foot in the third quarter.

AP-ES-12-02-07 1933EST